🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

 

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3956 PONCE DE LEON, St. Augustine, Florida 32084 MLS 2096359

3956 PONCE DE LEON, St. Augustine, Florida 32084

35Picture(s)

7,672Sqft

A special Commercial property is now available just north of the Historic District, and south of the Municipal Airport .

$1,575,000

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4065 MAGILL, Jacksonville, Florida 32220 MLS 2135442

4065 MAGILL, Jacksonville, Florida 32220

44Picture(s)

1,828Sqft

Road Frontage: 3.99 Acres Zoned (CN) Commercial Neighborhood. Usage will be in the documents tab. Building is rented out till July 1st for $2300 a month. Please call Listing agent to tour & Discuss property 904.864.

$1,500,000

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5646-C STATE ROAD 16, St. Augustine, Florida 32092 MLS 2112021

5646-C STATE ROAD 16, St. Augustine, Florida 32092

11Picture(s)

3,286Sqft

DEVELOPMENT OPPORTUNITY! WORLD GOLF VILLAGE CORRIDER!!! Package total of 6.61 ACRES WITH 280 FEET OF ROAD FRONTAGE DIRECTLY ON HEAVILY TRAVELLED STATE ROAD 16 . This particular parcel is 1.97 Acres being sold as a package with the adjacent 4.94 Acres. Currently zoned multifamily, the parcel contains multiple buildings including a 4/2.5 Single Family residence, and a 2/2 doublewide Mobile Home .

$1,500,000

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755 HIGHWAY 17, San Mateo, Florida 32187 MLS 2106325

755 HIGHWAY 17, San Mateo, Florida 32187

24Picture(s)

3,975Sqft

Strategically positioned at the high-traffic intersection of US Highway 17 and Horse Landing Road, this Commercial/R-2 property presents a compelling opportunity for developers and investors alike.

$1,500,000

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711 CASSAT, Jacksonville, Florida 32205 MLS 2105205

711 CASSAT, Jacksonville, Florida 32205

23Picture(s)

6,909Sqft

711 Cassat Avenue, located in Jacksonville, Florida, offers a vibrant and convenient location for various uses. This property features a spacious layout with ample square footage, providing flexibility for retail, office or industrial use purposes.

$1,500,000

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1906 DEBARRY, Orange Park, Florida 32073 MLS 2097571

1906 DEBARRY, Orange Park, Florida 32073

39Picture(s)

3,408Sqft

Attention Doctors and Medical Professionals and business owners! Currently epuipped as an exceptional medical facility in Orange Park, FL, featuring two fully-equipped units ideal for various healthcare practices.

$1,500,000

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1211 CYPRESS, St. Augustine, Florida 32086 MLS 1244415

1211 CYPRESS, St. Augustine, Florida 32086

42Picture(s)

0Sqft

INVESTOR ALERT! Property includes both 1211 and part of 1235 Cypress Rd. Two parcel IDs (099150-0000 and 099160-0000). Includes park owned rental mobile homes and pad rentals. All 14 sites are 1/2 acre (APPROX.) parcels and have individual wells and individual septic.

$1,500,000

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14961 NORMANDY, Jacksonville, Florida 32234 MLS 2133109

14961 NORMANDY, Jacksonville, Florida 32234

18Picture(s)

0Sqft

Excellent Commercial zoned land in the quickly developing area near Cecil Field allows for a wide variety of commercial uses. The mostly cleared site consists of 4 acres located conveniently on Normandy Blvd near a variety of new and existing residential developments this site has access to all utilities.

$1,499,999

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6 ST JOHNS MEDICAL PARK, St. Augustine, Florida 32086 MLS 2122701

6 ST JOHNS MEDICAL PARK, St. Augustine, Florida 32086

79Picture(s)

4,028Sqft

Occupancy available April 2026. Unique opportunity to move your busy practice into the entire building or convert back to Suite A and B, lease the additional space and share building expenses. The building was originally constructed with separate electric and water meters, separate entrances and offices.

$1,499,900

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3653 REGENT, Jacksonville, Florida 32224 MLS 2138136

3653 REGENT, Jacksonville, Florida 32224

18Picture(s)

4,592Sqft

**END UNIT WAREHOUSE**DOUBLE UNIT**LOADING DOCK** This versatile commercial warehouse is a double end unit with 2 entrances, located in a small gated and fenced/secured, quiet and safe subdivision. The block building and FULLY INSULATED structure features 2 overhead drive-in doors 10'x 12' and a tall ceiling height from 16' to 22' span.

$1,499,000

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11606 COLUMBIA PARK, Jacksonville, Florida 32258 MLS 2136328

11606 COLUMBIA PARK, Jacksonville, Florida 32258

4Picture(s)

6,450Sqft

Prime commercial real estate for sale in Jacksonville, FL (32258) located in the highly desirable Mandarin submarket. This property features convenient access to I-95, I-295, and Philips Hwy (US-1), supporting strong commuter flow and business visibility. Positioned near dense residential rooftops and established retail corridors, this site benefits from consistent traffic and growth.

$1,495,000

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1915 A1A, St. Augustine, Florida 32080 MLS 2120321

1915 A1A, St. Augustine, Florida 32080

22Picture(s)

4,000Sqft

Nestled at the pinnacle of Anastasia Island's most prominent vantage point— the high-visibility corner of SR 312 and A1A Business—this 4,000 sq ft commercial condo stands as a beacon for entrepreneurs and savvy investors. Boasting frontage on one of St.

$1,495,000

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🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

• Buying land to build a new facility

• Selling an existing business property

• Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.