🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

 

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410 BERESFORD, DeLand, Florida 32720 MLS 2018468

410 BERESFORD, DeLand, Florida 32720

8Picture(s)

2,813Sqft

Seller says SELL! PRICE DRASTICALLY REDUCED! Perfect facility & location for BBQ or other restaurant, bar & grill, sports bar, catering kitchen, event venue, club, or convert to other uses – retail, commercial, office. Original BBQ pits are intact. The adjacent vacant lot is included which increases the overall lot area to over 1/4 acre.

$149,900

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0 St. Johns, Palatka, Florida 32177 MLS 338136

0 St. Johns, Palatka, Florida 32177

1Picture(s)

0Sqft

2 +/- acres, zoned C-2, with frontage on both St. Johns Ave & Kay Larkin Dr. Additional land available. Located near the hospital.

$149,900

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1330 BLANDING, Orange Park, Florida 32065 MLS 2123780

1330 BLANDING, Orange Park, Florida 32065

6Picture(s)

3,000Sqft

Great Location, Available for sale Sandwich shop business only with drive-thru Located in a very busy Shopping center with many successful retail stores. Fully equipped with dine- in … the space is approximately 3000 sq/ft. **** The current owner of this specific location has a franchise agreement with one of the most reputable and very successful names in the Sandwich shop business.

$140,000

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476 HIGHWAY 17, Palatka, Florida 32177 MLS 2126901

476 HIGHWAY 17, Palatka, Florida 32177

6Picture(s)

0Sqft

Opportunity to own commercial property with great highway frontage. Cleared and ready for new business adventure. Many possibilities and plenty of great exposure.

$135,000

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224 THOMPSON, Starke, Florida 32091 MLS 2122371

224 THOMPSON, Starke, Florida 32091

14Picture(s)

2,185Sqft

Originally located in a residential area it has been rezoned commercial. Some updates and repairs were done within the last several months. This building has been divided into 2 separate units. Will make a great office location with downtown Starke and Historic Call Street only 1 block to the north. Additional photos coming soon.

$130,000

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106 ST. GEORGE STREET, St. Augustine, Florida 32084 MLS 2087504

106 ST. GEORGE STREET, St. Augustine, Florida 32084

1Picture(s)

600Sqft

Don't miss your chance to own not one, but two profitable and well-established retail businesses in the heart of historic downtown St. Augustine. Both retail spaces are ideally positioned along the highly trafficked and pedestrian-only St. George Street, ensuring visibility and foot traffic year-round. This turnkey package deal includes: One retail space approx.

$125,000

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226 THOMPSON, Starke, Florida 32091 MLS 2123701

226 THOMPSON, Starke, Florida 32091

10Picture(s)

1,581Sqft

Originally located in a residential area it has been rezoned commercial. Some updates and repairs were done within the last several months. This building will make a great office location with downtown Starke and Historic Call Street only 1 block to the north. Purchaser can apply to have it rezoned to residential and turn it into rental property.

$120,000

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345 COUNTY ROAD 315, Interlachen, Florida 32148 MLS 2113107

345 COUNTY ROAD 315, Interlachen, Florida 32148

3Picture(s)

0Sqft

COMMERCIAL PROPERTY LOCATED IN PUTNAM COUNTY – Are you ready to build your Commercial dreams? We have the perfect acreage for you. This property has State Road frontage in INTERLACHEN – 1.26 acres on South Hwy 315. Zoned Commercial with adjacent property for sale. Within Putnam County (lower taxes).

$120,000

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1318 ORANGE, Green Cove Springs, Florida 32043 MLS 2073124

1318 ORANGE, Green Cove Springs, Florida 32043

6Picture(s)

2,501Sqft

Convenient Store BUSINESS ONLY For Sale Very reasonable rent. Great location Inventory not included in the Selling Price.

$120,000

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4923 MAIN, Jacksonville, Florida 32206 MLS 2126407

4923 MAIN, Jacksonville, Florida 32206

12Picture(s)

0Sqft

Great corner lot on a busy commercial street, Commercial lot a little over a quarter of an acre.

$110,000

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341 COUNTY ROAD 315, Interlachen, Florida 32148 MLS 2113431

341 COUNTY ROAD 315, Interlachen, Florida 32148

6Picture(s)

0Sqft

COMMERCIAL PROPERTY LOCATED IN PUTNAM COUNTY – Are you ready to build your Commercial dreams? We have the perfect acreage for you. This property features state road frontage in Interlachen, with 0.77 acres on South Hwy 315. Zoned Commercial with adjacent property for sale. Within Putnam County (lower taxes).

$100,000

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541 TALLEYRAND, Jacksonville, Florida 32202 MLS 2103364

541 TALLEYRAND, Jacksonville, Florida 32202

3Picture(s)

1,336Sqft

Here is your opportunity to own a turnkey business near downtown Jacksonville. The business has all items needed to run a restaurant and convenience store.

$100,000

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🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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• Property Type (Retail, Office, Industrial, Land, Multi-Use)

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

• Buying land to build a new facility

• Selling an existing business property

• Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.