Commercial Property for Sale In North East Florida Jacksonville - Orange Park - St Augustine - Middleburg - Beaches

🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

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4310 BARKOSKIE, Jacksonville, Florida 32258 MLS 2098223

4310 BARKOSKIE, Jacksonville, Florida 32258

31Picture(s)
6,206Sqft
Prime opportunity to purchase a 6,206 SF standalone building situated on a spacious 0.84-acre lot along high-traffic Old St. Augustine Road. This turn-key facility is ideal for schools, daycare centers, medical offices, or professional office use, offering flexible PUD zoning to accommodate a wide range of business types, including retail.
$1,695,000

2758 US HIGHWAY 1, St. Augustine, Florida 32086 MLS 2103280

2758 US HIGHWAY 1, St. Augustine, Florida 32086

6Picture(s)
2,474Sqft
Commercial Building for Sale in St Augustine previously used as a medical office.
$1,690,000

222 SAN MARCO, St. Augustine, Florida 32084 MLS 2116538

222 SAN MARCO, St. Augustine, Florida 32084

1Picture(s)
3,540Sqft
This 4,116 sq. ft. office building features 120 feet of frontage along San Marco/A1A and includes a covered patio. The property offers 3,540 sq. ft. of heated and cooled space, currently divided into three office suites, each with private entrances. With 17 on-site parking spaces, this property presents endless opportunities for establishing your own business in the heart of downtown St.
$1,500,000

5646-C STATE ROAD 16, St. Augustine, Florida 32092 MLS 2112021

5646-C STATE ROAD 16, St. Augustine, Florida 32092

11Picture(s)
3,286Sqft
DEVELOPMENT OPPORTUNITY! WORLD GOLF VILLAGE CORRIDER!!! Package total of 6.61 ACRES WITH 280 FEET OF ROAD FRONTAGE DIRECTLY ON HEAVILY TRAVELLED STATE ROAD 16 . This particular parcel is 1.97 Acres being sold as a package with the adjacent 4.94 Acres. Currently zoned multifamily, the parcel contains multiple buildings including a 4/2.5 Single Family residence, and a 2/2 doublewide Mobile Home .
$1,500,000

755 HIGHWAY 17, San Mateo, Florida 32187 MLS 2106325

755 HIGHWAY 17, San Mateo, Florida 32187

24Picture(s)
3,975Sqft
Strategically positioned at the high-traffic intersection of US Highway 17 and Horse Landing Road, this Commercial/R-2 property presents a compelling opportunity for developers and investors alike.
$1,500,000

711 CASSAT, Jacksonville, Florida 32205 MLS 2105205

711 CASSAT, Jacksonville, Florida 32205

4Picture(s)
6,909Sqft
711 Cassat Avenue, located in Jacksonville, Florida, offers a vibrant and convenient location for various uses. This property features a spacious layout with ample square footage, providing flexibility for retail, office or industrial use purposes.
$1,500,000

18811 243RD, Hawthorne, Florida 32640 MLS 2102955

18811 243RD, Hawthorne, Florida 32640

25Picture(s)
1,801Sqft
CERTIFIED ORGANIC BLUEBERRY FARM – Need to come out to the country and check out this beautiful farm. This property is approximately 38.19 acres with eight different varies of blueberries all located in Lochloosa Farms.
$1,500,000

2201 PONCE DE LEON, St. Augustine, Florida 32084 MLS 2102293

2201 PONCE DE LEON, St. Augustine, Florida 32084

46Picture(s)
670Sqft
Turnkey Auto Repair Business & Real Estate For Sale – Great Location, Established Clientele! An incredible opportunity to own both the business and the building! This well-established auto repair shop is located in a high-traffic area with excellent visibility and easy access. The sale includes the full business operation plus the real estate, making this a rare, valuable investment.
$1,500,000

1906 DEBARRY, Orange Park, Florida 32073 MLS 2097571

1906 DEBARRY, Orange Park, Florida 32073

38Picture(s)
3,408Sqft
Attention Doctors and Medical Professionals! Exceptional medical facility available at 1906 DeBarry Avenue in Orange Park, FL, featuring two fully-equipped units ideal for various healthcare practices. Unit 1 offers 6 patient rooms, 3 bathrooms, a combined kitchen/lab area, and a separate restroom with privacy door.
$1,500,000

1602 WALNUT, Jacksonville, Florida 32206 MLS 2095764

1602 WALNUT, Jacksonville, Florida 32206

10Picture(s)
6,000Sqft
Property includes: 072304-0100, 072304-0130, 072304-0120, 072304-0110. Offering an exceptional investment opportunity for an owner-user or investor seeking versatile space in Jacksonville's Historic Springfield – both a nationally and locally designated historic district.
$1,500,000

433 SILVER BEACH, Daytona Beach, Florida 32118 MLS 2095512

433 SILVER BEACH, Daytona Beach, Florida 32118

9Picture(s)
15,360Sqft
Immaculately kept professional office suite showcasing private offices and a versatile conference/work room. Abundant natural light floods the space through large windows on all sides. Shared restroom facilities enhance convenience. Positioned in a high-visibility location within the Downtown Area, close to courthouses, shopping and tourist attractions.
$1,500,000

4371 LOSCO, Jacksonville, Florida 32257 MLS 2063775

4371 LOSCO, Jacksonville, Florida 32257

10Picture(s)
4,422Sqft
Excellent opportunity to own or develop a high-visibility commercial property in the heart of Jacksonville. Located on Losco Road just minutes from I-295 and San Jose Blvd, this site offers outstanding accessibility to major traffic corridors, residential communities, and thriving retail centers.
$1,500,000
442 Results returned.Per Page

🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

  • Buying land to build a new facility

  • Selling an existing business property

  • Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.

Mike

See Come Vacant Lots – land for sale here HERE
If you are looking to buy or sell a home on Black Creek you have come to the right place. I would love to help you find your next home. When you see something you like please call, text, or email me anytime and I will get to work for you. Call Mike Schwiebert Realtor at 904-562-9345. Voted Best Real Estate Agent 2019 in Clay County!

Mike Schwiebert Best Realtor In Clay County