🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

 

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8314 HERLONG, Jacksonville, Florida 32210 MLS 2133837

8314 HERLONG, Jacksonville, Florida 32210

30Picture(s)

6,503Sqft

The large building is a decommissioned Church. The building is spacious to include offices, meeting area, kitchen and restrooms for both men and women. One of the buildings is a large storage facility and one was at one time a house, but not at this time The opportunities are immense with the current buildings and/or the parcels. The main building could be used for a school, a daycare, etc.

$1,100,000

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4607 OCEAN, Jacksonville, Florida 32233 MLS 2127393

4607 OCEAN, Jacksonville, Florida 32233

52Picture(s)

2,572Sqft

Top of the line new construction, two story mixed use building with water view in Mayport Village! We are proud to present this opportunity to invest in Mayport with this premium, turnkey high traffic real estate asset! VACANT LOT next door included in this sales price, also zoned CCG-1, which allows for a broad range of uses, making this a development opportunity as well.

$1,100,000

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2570 US HIGHWAY 1, St. Augustine, Florida 32086 MLS 2003980

2570 US HIGHWAY 1, St. Augustine, Florida 32086

12Picture(s)

3,920Sqft

Investment opportunity!! 100 feet of frontage on US 1 S in a prime location. 4 opportunities on one .56 acre lot. A residential home that is currently rented yearly (May renewal), a beauty shop with 8 booth rentals, a gun shop that is currently leased, and a separate oversized garage that can be rented as well. Walmart is situated across the street and Auto Zone is next door.

$1,100,000

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6905 OLD WOLF BAY, Palatka, Florida 32177 MLS 2120057

6905 OLD WOLF BAY, Palatka, Florida 32177

38Picture(s)

6,420Sqft

Prime medical office space in a premier location! Currently used as Putnam Diagnostic Imaging Center, this 6,420 sq ft building is located in a well-established medical district, just SW of HCA Florida Putnam Hospital.

$1,100,000

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1503 OAK, Jacksonville, Florida 32204 MLS 2096449

1503 OAK, Jacksonville, Florida 32204

50Picture(s)

2,694Sqft

Exceptional 2,694 SF established medical office building located in the heart of Riverside's bustling 5-Points district. This turnkey opportunity features proven commercial use with flexible zoning, making it ideal for healthcare practitioners or professional services.

$1,100,000

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831 8TH, Fernandina Beach, Florida 32034 MLS 2135690

831 8TH, Fernandina Beach, Florida 32034

57Picture(s)

3,360Sqft

Check out the video walkthrough available on YouTube and also attached to the listing. Prime industrial contractor facility for sale in Fernandina Beach, FL offering an excellent opportunity for an owner-user or investor.

$1,098,000

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531 UNION, Jacksonville, Florida 32202 MLS 2102615

531 UNION, Jacksonville, Florida 32202

4Picture(s)

1,050Sqft

Welcome to UNION AND BROAD! The subject property is located at 531 W. Union Street Jacksonville, FL 32202. The base area is 1050 sq/ft and the total effective area is 1138 sq/ft. Renovated in 2017, this property has three offices, one bathroom, conference room and a flexible kitchen lounge with approx.10 parking spaces available.

$1,095,000

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481 HIGHWAY 17, Palatka, Florida 32177 MLS 2007477

481 HIGHWAY 17, Palatka, Florida 32177

32Picture(s)

17,834Sqft

Opportunity of the Century! This 9.29 Acre parcel is Zoned C-2 Commercial with a Future Land Use of IL (Light Industrial).

$1,090,000

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5209 SAN JOSE, Jacksonville, Florida 32207 MLS 2134084

5209 SAN JOSE, Jacksonville, Florida 32207

18Picture(s)

5,184Sqft

5209 San Jose Boulevard presents a prime opportunity for investors or owner-users seeking a multi-tenant office property. Positioned directly on San Jose Boulevard with over 24,500 AADT, the property features a ± 5,184 SF freestanding building situated on approximately 0.22 acres. The site is zoned Commercial Office (CO), allowing for a wide range of office and professional uses.

$1,075,000

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1825 ST JOHNS, Palatka, Florida 32177 MLS 2065427

1825 ST JOHNS, Palatka, Florida 32177

48Picture(s)

19,488Sqft

Iconic Palatka Property – Historic Newspaper Headquarters Available Prime Location & Versatility: 19,488 sq ft building on 1.84 acres in the heart of Palatka, FL. Home to the Palatka Daily News since 1967, offering rich history and local recognition. 11,960 sq ft of office space, ideal for a variety of businesses.

$1,050,000

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1887 MAYPORT, Atlantic Beach, Florida 32233 MLS 2126039

1887 MAYPORT, Atlantic Beach, Florida 32233

50Picture(s)

1,574Sqft

Discover a unique building in a prime commercial location on Mayport Road, in Atlantic Beach. This concrete block structure features an appealing brick exterior and boasts an inviting open floor plan, ideal for flexible workspace configurations. As you enter, you'll appreciate the convenient handicap ramp, ensuring accessibility for all.

$1,050,000

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5646-A STATE ROAD 16, St. Augustine, Florida 32092 MLS 2112018

5646-A STATE ROAD 16, St. Augustine, Florida 32092

14Picture(s)

1,452Sqft

DEVELOPMENT OPPORTUNITY! WORLD GOLF VILLAGE CORRIDER!!! Package total of 6.61 ACRES WITH 280.43 FEET OF ROAD FRONTAGE DIRECTLY ON HEAVILY TRAVELLED STATE ROAD 16 . This particular parcel is .64 Acres with 100 feet of road frontage, being sold as a package with the adjacent 5.97 Acres. Currently zoned single family, the parcel contains a 1452SF 3/2 Single Family residence …

$1,000,000

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🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

• Buying land to build a new facility

• Selling an existing business property

• Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.