🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

 

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1825 ST JOHNS, Palatka, Florida 32177 MLS 2065427

1825 ST JOHNS, Palatka, Florida 32177

48Picture(s)

19,488Sqft

Iconic Palatka Property – Historic Newspaper Headquarters Available Prime Location & Versatility: 19,488 sq ft building on 1.84 acres in the heart of Palatka, FL. Home to the Palatka Daily News since 1967, offering rich history and local recognition. 11,960 sq ft of office space, ideal for a variety of businesses.

$1,050,000

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5646-A STATE ROAD 16, St. Augustine, Florida 32092 MLS 2112018

5646-A STATE ROAD 16, St. Augustine, Florida 32092

14Picture(s)

1,452Sqft

DEVELOPMENT OPPORTUNITY! WORLD GOLF VILLAGE CORRIDER!!! Package total of 6.61 ACRES WITH 280.43 FEET OF ROAD FRONTAGE DIRECTLY ON HEAVILY TRAVELLED STATE ROAD 16 . This particular parcel is .64 Acres with 100 feet of road frontage, being sold as a package with the adjacent 5.97 Acres. Currently zoned single family, the parcel contains a 1452SF 3/2 Single Family residence …

$1,000,000

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3973 EAGLE LANDING, Orange Park, Florida 32065 MLS 2105209

3973 EAGLE LANDING, Orange Park, Florida 32065

14Picture(s)

5,447Sqft

Former Eagle Landing Welcome Center for East West Realty. Two-story commercial building with lobby/reception area on first floor and multiple private offices upstairs. Flexible layout ideal for professional services, retail, sales office or small business headquarters. Over 5065 square of interior space and 1142 covered outdoor area. Ample parking and convenient access.

$1,000,000

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2706 OLD MOULTRIE, St. Augustine, Florida 32086 MLS 2104450

2706 OLD MOULTRIE, St. Augustine, Florida 32086

31Picture(s)

2,276Sqft

A great opportunity with multiple uses to include medical office, professional office, veterinary office, day care, senior care, retail, churches, restaurant or even your own personal compound with tremendous upside! The existing 2,276 SF standalone building is in excellence condition and ready to take on any business or family for that matter. You have 2.18 Acres of Uplands on the 3.

$999,999

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550 BALMORAL, Jacksonville, Florida 32218 MLS 2092953

550 BALMORAL, Jacksonville, Florida 32218

21Picture(s)

4,253Sqft

The Busch Professional Office Pavilion Investment offers a rare opportunity in North Jacksonville's thriving Busch Drive Business Park. This low vacancy office complex features many brand-new 5-year leases across its office suites, ensuring stable and predictable income.

$999,999

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6491 103RD, Jacksonville, Florida 32210 MLS 2124748

6491 103RD, Jacksonville, Florida 32210

3Picture(s)

1,270Sqft

.70 acres zoned CCG-1 sits adjacent to HCA Emergency Center (Orange Park Medical Center). Corner adjoining property 6431 103rd is active with Watson Commercial Property. Unlimited possibilities! Opportunity to own commercial property in an aspiring area off 103rd Street. This listing includes 3 separate parcels of property…

$999,000

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5465 COUNTY ROAD 218, Middleburg, Florida 32068 MLS 2040789

5465 COUNTY ROAD 218, Middleburg, Florida 32068

23Picture(s)

0Sqft

With a zoning classification of BB3 and AR, this 8.26-acre property on CR218 presents an opportunity for commercial development. Located just 6 miles from Blanding Blvd (SR21) with easy access to First Coast Expressway, the location benefits from its proximity to Blanding Blvd to the East & 301 to the West, ensuring a high level of visibility & accessibility in this upcoming area. Front 2.

$999,000

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8818 GOODBYS EXECUTIVE, Jacksonville, Florida 32217 MLS 2120537

8818 GOODBYS EXECUTIVE, Jacksonville, Florida 32217

17Picture(s)

4,259Sqft

Fully renovated waterfront office property in fantastic location within Goodbys Creek Executive Park. Expansive water views from all offices, ample parking area, and an excellent location make this a must see property. See documents for list of improvements.

$998,000

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300 MAIN, Lake Butler, Florida 32054 MLS 2097639

300 MAIN, Lake Butler, Florida 32054

71Picture(s)

12,603Sqft

Former Bank building in the heart of Lake Butler available for new business opportunities. Almost 9000 Sq Ft of interior space for you to work with and ample parking outside. 2 multi stall bathrooms for customers as well as a finished breakroom with refrigerator and stove for your employees. There is an upstairs space for storage as well.

$990,000

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1017 BLANDING, Orange Park, Florida 32065 MLS 2113620

1017 BLANDING, Orange Park, Florida 32065

44Picture(s)

9,650Sqft

Prime Commercial Property, ideally located in high traffic area of Blanding Blvd. Currently mixed-use retail for furniture, antiques, boutique clothing.

$975,000

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24 COLLEGE, Macclenny, Florida 32063 MLS 2111019

24 COLLEGE, Macclenny, Florida 32063

1Picture(s)

9,200Sqft

PRIME MIXED-USE INVESTMENT OPPORTUNITY. Located in the heart of Macclenny's central business district, this fully occupied mixed-use property offers +-9,200 sq ft on a 0.24-acre parcel with 90 feet of frontage on US Route 90. Positioned at the hub of commerce and community life, the building benefits from high visibility and strong pedestrian and vehicle traffic.

$975,000

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542766 US HIGHWAY 1, Callahan, Florida 32011 MLS 2104583

542766 US HIGHWAY 1, Callahan, Florida 32011

2Picture(s)

1,222Sqft

Want to get your business on the map in Callahan? DO NOT miss out on this opportunity! 3.5+/- acres zoned Commercial Intensive inside the city limits. Highway frontage offers high traffic count and convenient access.

$975,000

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🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

• Buying land to build a new facility

• Selling an existing business property

• Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.