🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

 

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274 MCDUFF, Jacksonville, Florida 32254 MLS 2120120

274 MCDUFF, Jacksonville, Florida 32254

14Picture(s)

1,216Sqft

Cozy CLASSIC STYLE house ON A CORNER LOT. Great for Residential (3/1) or Commerical (Zoned commerical) NEW HVAC SYSTEM & electric system, plumbing updated in '23 and NEW ROOF DONE 3 YEARS AGO. High ceilings LARGE WINDOWS ALL AROUND and spacious floor plan. Private fenced and gated, good size backyard. 5 MINUTES FROM DOWNTOWN, 18 MINUTES TO JAX INT'L AIRPORT.

$130,000

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106 ST. GEORGE STREET, St. Augustine, Florida 32084 MLS 2087504

106 ST. GEORGE STREET, St. Augustine, Florida 32084

1Picture(s)

600Sqft

Don't miss your chance to own not one, but two profitable and well-established retail businesses in the heart of historic downtown St. Augustine. Both retail spaces are ideally positioned along the highly trafficked and pedestrian-only St. George Street, ensuring visibility and foot traffic year-round. This turnkey package deal includes: One retail space approx.

$125,000

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226 THOMPSON, Starke, Florida 32091 MLS 2123701

226 THOMPSON, Starke, Florida 32091

10Picture(s)

1,581Sqft

Originally located in a residential area it has been rezoned commercial. Some updates and repairs were done within the last several months. This building will make a great office location with downtown Starke and Historic Call Street only 1 block to the north. Purchaser can apply to have it rezoned to residential and turn it into rental property.

$120,000

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345 COUNTY ROAD 315, Interlachen, Florida 32148 MLS 2113107

345 COUNTY ROAD 315, Interlachen, Florida 32148

3Picture(s)

0Sqft

COMMERCIAL PROPERTY LOCATED IN PUTNAM COUNTY – Are you ready to build your Commercial dreams? We have the perfect acreage for you. This property has State Road frontage in INTERLACHEN – 1.26 acres on South Hwy 315. Zoned Commercial with adjacent property for sale. Within Putnam County (lower taxes).

$120,000

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5506 AVENUE B, Jacksonville, Florida 32209 MLS 2115500

5506 AVENUE B, Jacksonville, Florida 32209

41Picture(s)

3,228Sqft

OPTIONS, OPTIONS, OPTIONS. INVESTORS, this building have many options, located on Residential/commercial area can be used either way, with great space for parking outside, with 2 offices sapce on the first floor and an apartment on the second floor that can be used as office space too. THIS WONT LAST….

$119,500

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4923 MAIN, Jacksonville, Florida 32206 MLS 2126407

4923 MAIN, Jacksonville, Florida 32206

12Picture(s)

0Sqft

Great corner lot on a busy commercial street, Commercial lot a little over a quarter of an acre.

$110,000

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2550 STATE, Bunnell, Florida 32110 MLS 2068085

2550 STATE, Bunnell, Florida 32110

21Picture(s)

1,000Sqft

Turnkey physical therapy business for sale with assumable lease. Landlord agreeable to executing a long-term lease with a qualified buyer. Facility is 1000 SF and features reception area, waiting area, office, restroom, and three treatment rooms. HVAC system was replaced in 2019. Established client base with both insured and private-pay clients.

$110,000

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341 COUNTY ROAD 315, Interlachen, Florida 32148 MLS 2113431

341 COUNTY ROAD 315, Interlachen, Florida 32148

6Picture(s)

0Sqft

COMMERCIAL PROPERTY LOCATED IN PUTNAM COUNTY – Are you ready to build your Commercial dreams? We have the perfect acreage for you. This property features state road frontage in Interlachen, with 0.77 acres on South Hwy 315. Zoned Commercial with adjacent property for sale. Within Putnam County (lower taxes).

$100,000

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541 TALLEYRAND, Jacksonville, Florida 32202 MLS 2103364

541 TALLEYRAND, Jacksonville, Florida 32202

3Picture(s)

1,336Sqft

Here is your opportunity to own a turnkey business near downtown Jacksonville. The business has all items needed to run a restaurant and convenience store.

$100,000

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155 FOUNTAINS WAY, St. Johns, Florida 32259 MLS 2125677

155 FOUNTAINS WAY, St. Johns, Florida 32259

16Picture(s)

2,616Sqft

Well-established açaí bowl and juice bar located in a high-traffic area of St. Johns. Juice Tap is a turnkey operation with a loyal customer base and strong local presence. The sale includes all existing inventory, equipment, and branding, making this an ideal opportunity for an owner operator or investor looking to step into the health and wellness space.

$80,000

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1310 ST JOHNS, Palatka, Florida 32177 MLS 2118231

1310 ST JOHNS, Palatka, Florida 32177

12Picture(s)

934Sqft

Fantastic commercial opportunity in the City of Palatka! This 932 sq ft property is zoned C-2, offering excellent flexibility for a wide range of business uses. The interior has already been fully gutted, providing a clean slate that's ready for your custom build-out and vision.

$64,900

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1545 COUNTY ROAD 220, Fleming Island, Florida 32003 MLS 2112410

1545 COUNTY ROAD 220, Fleming Island, Florida 32003

5Picture(s)

73,652Sqft

Well established Beauty Salon business only available for sale. located in a very busy Shopping center with many successful retail stores. *** Great opportunity for owner operator to aquire this business with potential to add many other services in the Beauty industry.

$60,000

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🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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• Property Type (Retail, Office, Industrial, Land, Multi-Use)

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

• Buying land to build a new facility

• Selling an existing business property

• Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.