🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

 

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0 St. Johns, Palatka, Florida 32177 MLS 338136

0 St. Johns, Palatka, Florida 32177

1Picture(s)

0Sqft

2 +/- acres, zoned C-2, with frontage on both St. Johns Ave & Kay Larkin Dr. Additional land available. Located near the hospital.

$149,900

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5454 TIMUQUANA, Jacksonville, Florida 32210 MLS 2130077

5454 TIMUQUANA, Jacksonville, Florida 32210

8Picture(s)

1,057Sqft

Exceptional commercial potential at 5454 Timuquana Road, a well-maintained property featuring a metal roof and durable exterior. Zoned Commercial Neighborhood (CN), this site offers a flexible footprint for a variety of professional, retail, or service-oriented business uses.

$145,000

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1330 BLANDING, Orange Park, Florida 32065 MLS 2123780

1330 BLANDING, Orange Park, Florida 32065

6Picture(s)

3,000Sqft

Great Location, Available for sale Sandwich shop business only with drive-thru Located in a very busy Shopping center with many successful retail stores. Fully equipped with dine- in … the space is approximately 3000 sq/ft. **** The current owner of this specific location has a franchise agreement with one of the most reputable and very successful names in the Sandwich shop business.

$140,000

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1445 DOUGLAS, Jacksonville, Florida 32211 MLS 2093927

1445 DOUGLAS, Jacksonville, Florida 32211

12Picture(s)

672Sqft

Move in Ready stand alone building in high traffic area zoned CCG1 Commercial. Property Features many updates including ,plumbing, electric ,HVAC. Desirable location connected to City Water & Sewer with easy access to downtown, beaches and southside. Situated on a nice fenced in corner lot with frontage on both Macy and Douglas St. Please call listing agent for any details.

$135,000

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9735 OLD ST AUGUSTINE, Jacksonville, Florida 32257 MLS 2075041

9735 OLD ST AUGUSTINE, Jacksonville, Florida 32257

23Picture(s)

2,400Sqft

An incredible opportunity awaits with this well-established Deli & Grill Restaurant. This turnkey business serves delicious breakfast and lunch in a warm and inviting atmosphere, perfect for casual dining and quick bites. Prime Location, Situated in a high-traffic area with excellent visibility and easy access.

$132,000

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224 THOMPSON, Starke, Florida 32091 MLS 2122371

224 THOMPSON, Starke, Florida 32091

14Picture(s)

2,185Sqft

Originally located in a residential area it has been rezoned commercial. Some updates and repairs were done within the last several months. This building has been divided into 2 separate units. Will make a great office location with downtown Starke and Historic Call Street only 1 block to the north. Additional photos coming soon.

$130,000

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476 HIGHWAY 17, Palatka, Florida 32177 MLS 2126901

476 HIGHWAY 17, Palatka, Florida 32177

6Picture(s)

0Sqft

Opportunity to own commercial property with great highway frontage. Cleared and ready for new business adventure. Many possibilities and plenty of great exposure.

$125,000

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106 ST. GEORGE STREET, St. Augustine, Florida 32084 MLS 2087504

106 ST. GEORGE STREET, St. Augustine, Florida 32084

1Picture(s)

600Sqft

Don't miss your chance to own not one, but two profitable and well-established retail businesses in the heart of historic downtown St. Augustine. Both retail spaces are ideally positioned along the highly trafficked and pedestrian-only St. George Street, ensuring visibility and foot traffic year-round. This turnkey package deal includes: One retail space approx.

$125,000

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226 THOMPSON, Starke, Florida 32091 MLS 2123701

226 THOMPSON, Starke, Florida 32091

10Picture(s)

1,581Sqft

Originally located in a residential area it has been rezoned commercial. Some updates and repairs were done within the last several months. This building will make a great office location with downtown Starke and Historic Call Street only 1 block to the north. Purchaser can apply to have it rezoned to residential and turn it into rental property.

$120,000

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345 COUNTY ROAD 315, Interlachen, Florida 32148 MLS 2113107

345 COUNTY ROAD 315, Interlachen, Florida 32148

3Picture(s)

0Sqft

COMMERCIAL PROPERTY LOCATED IN PUTNAM COUNTY – Are you ready to build your Commercial dreams? We have the perfect acreage for you. This property has State Road frontage in INTERLACHEN – 1.26 acres on South Hwy 315. Zoned Commercial with adjacent property for sale. Within Putnam County (lower taxes).

$120,000

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1318 ORANGE, Green Cove Springs, Florida 32043 MLS 2073124

1318 ORANGE, Green Cove Springs, Florida 32043

6Picture(s)

2,501Sqft

Convenient Store BUSINESS ONLY For Sale Very reasonable rent. Great location Inventory not included in the Selling Price.

$120,000

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4923 MAIN, Jacksonville, Florida 32206 MLS 2126407

4923 MAIN, Jacksonville, Florida 32206

12Picture(s)

0Sqft

Great corner lot on a busy commercial street, Commercial lot a little over a quarter of an acre.

$110,000

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🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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• Property Type (Retail, Office, Industrial, Land, Multi-Use)

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

• Buying land to build a new facility

• Selling an existing business property

• Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.