🏢 Commercial Property For Sale In Northeast Florida

Grow your business or expand your investment portfolio in one of Florida’s fastest-growing regions.

If you’re searching for commercial real estate in Northeast Florida, you’re in the right place. Whether you need retail space, office buildings, warehouses, or land for future development, Northeast Florida offers a wide range of opportunities for both investors and business owners.

From the bustling corridors of Jacksonville to the emerging growth areas of Clay County, St. Johns County, and Bradford County, this region combines a strong economy, expanding population, and business-friendly environment — making it one of Florida’s top destinations for commercial investment. See more details below.

 

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850 STATE ROAD 21, Melrose, Florida 32666 MLS 2000229

850 STATE ROAD 21, Melrose, Florida 32666

6Picture(s)

0Sqft

Melrose commercial opportunity- Located one block from the junction of SR 21 & SR 26 in the heart of Melrose is the perfect site to start your new retail or service business. With 100 feet of SR 21 frontage, this 0.31 acre site offers great exposure with a traffic count of over 9,500 cares daily. Zoned C-2 commercial the site offers city water, and is flat and ready to build.

$155,000

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2810 FLORIDA, Lakeland, Florida 33803 MLS 2121006

2810 FLORIDA, Lakeland, Florida 33803

11Picture(s)

3,600Sqft

Step into an easy, turn-key opportunity with Holy Moly Smoke Shop — a well-established business in a high-traffic Lakeland corridor. This clean, organized, and fully stocked shop has built a steady flow of loyal customers thanks to its strong product mix, convenient location, and welcoming atmosphere.

$150,000

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917 FERRIS, Green Cove Springs, Florida 32043 MLS 2110615

917 FERRIS, Green Cove Springs, Florida 32043

7Picture(s)

0Sqft

Prime commercial opportunity in the heart of Green Cove Springs! This 917 Ferris Street parcel offers an ideal location just minutes from the First Coast Expressway, providing exceptional visibility and accessibility in a highly desirable area.

$150,000

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1318 ORANGE, Green Cove Springs, Florida 32043 MLS 2073124

1318 ORANGE, Green Cove Springs, Florida 32043

6Picture(s)

2,501Sqft

Convenient Store BUSINESS ONLY For Sale Very reasonable rent. Great location Inventory not included in the Selling Price.

$150,000

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410 BERESFORD, DeLand, Florida 32720 MLS 2018468

410 BERESFORD, DeLand, Florida 32720

8Picture(s)

2,813Sqft

Seller says SELL! PRICE DRASTICALLY REDUCED! Perfect facility & location for BBQ or other restaurant, bar & grill, sports bar, catering kitchen, event venue, club, or convert to other uses – retail, commercial, office. Original BBQ pits are intact. The adjacent vacant lot is included which increases the overall lot area to over 1/4 acre.

$149,900

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19510 HWY 301, Waldo, Florida 32694 MLS 2095056

19510 HWY 301, Waldo, Florida 32694

43Picture(s)

2,045Sqft

Former Mug Shots Bar & Lounge now offered for sale. This property features a prime location with excellent visibility and access from busy Hwy 301, making it ideal for a variety of commercial uses. The site benefits from strong traffic, especially on weekends during Florida Gators football and basketball home games, as well as major events such as the Gatornationals at the nearby racetrack.

$149,900

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0 St. Johns, Palatka, Florida 32177 MLS 338136

0 St. Johns, Palatka, Florida 32177

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0Sqft

2 +/- acres, zoned C-2, with frontage on both St. Johns Ave & Kay Larkin Dr. Additional land available. Located near the hospital.

$149,900

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1330 BLANDING, Orange Park, Florida 32065 MLS 2123780

1330 BLANDING, Orange Park, Florida 32065

6Picture(s)

3,000Sqft

Great Location, Available for sale Sandwich shop business only with drive-thru Located in a very busy Shopping center with many successful retail stores. Fully equipped with dine- in … the space is approximately 3000 sq/ft. **** The current owner of this specific location has a franchise agreement with one of the most reputable and very successful names in the Sandwich shop business.

$140,000

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476 HIGHWAY 17, Palatka, Florida 32177 MLS 2126901

476 HIGHWAY 17, Palatka, Florida 32177

6Picture(s)

0Sqft

Opportunity to own commercial property with great highway frontage. Cleared and ready for new business adventure. Many possibilities and plenty of great exposure.

$135,000

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9735 OLD ST AUGUSTINE, Jacksonville, Florida 32257 MLS 2075041

9735 OLD ST AUGUSTINE, Jacksonville, Florida 32257

23Picture(s)

2,400Sqft

An incredible opportunity awaits with this well-established Deli & Grill Restaurant. This turnkey business serves delicious breakfast and lunch in a warm and inviting atmosphere, perfect for casual dining and quick bites. Prime Location, Situated in a high-traffic area with excellent visibility and easy access.

$132,000

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224 THOMPSON, Starke, Florida 32091 MLS 2122371

224 THOMPSON, Starke, Florida 32091

14Picture(s)

2,185Sqft

Originally located in a residential area it has been rezoned commercial. Some updates and repairs were done within the last several months. This building has been divided into 2 separate units. Will make a great office location with downtown Starke and Historic Call Street only 1 block to the north. Additional photos coming soon.

$130,000

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00 SAPP, Starke, Florida 32091 MLS 2069413

00 SAPP, Starke, Florida 32091

10Picture(s)

0Sqft

2 LOTS – 1 SALE! Seller is selling parcels 02428-0-00200 and 02428-0-00102. When entering the property, this lot is zoned B3 Commercial Hwy (you can do pretty much anything with it), the second lot is zoned R1D Single Family/Mobile Homes. The second lot can more than likely be re-zoned to B3 Commercial Hwy but not the other way around. These parcels are located within Starke City Limits.

$130,000

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🌴 Why Invest in Northeast Florida Commercial Real Estate

1. Strategic Location & Infrastructure
Northeast Florida sits at the crossroads of I-95, I-10, and major ports, making it ideal for logistics, retail, and industrial operations. Businesses benefit from proximity to Jacksonville International Airport, JAXPORT, and rail connections.

2. Population & Economic Growth
With rapid expansion in communities like Nocatee, Middleburg, Lake Asbury, and Green Cove Springs, local demand for retail, office, and service-based properties continues to climb.

3. Affordable Entry Point
Compared to South Florida and Central Florida markets, commercial land and buildings in Northeast Florida remain competitively priced, giving investors stronger ROI potential.

4. Diverse Property Types
Find everything from turnkey office complexes and retail plazas to vacant commercial land ready for development.

🔍 Search Commercial Properties for Sale in Northeast Florida

Use the interactive MLS search tool above to browse current commercial listings across Jacksonville, Orange Park, Green Cove Springs, Lake Asbury, Starke, Ponte Vedra, and surrounding areas.

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💼 Work with a Local Commercial Real Estate Expert

Mike Schwiebert, REALTOR® | 904HomeStore.com

As a licensed REALTOR®, former builder, and North Florida resident, Mike brings a unique perspective to commercial real estate. He understands zoning, site development, and investment analysis — helping you make informed decisions and negotiate the best deal.

Whether you’re:

• Buying land to build a new facility

• Selling an existing business property

• Expanding your investment portfolio

…Mike provides local expertise and a hands-on approach that helps clients get more value in every transaction.

📍 Serving Jacksonville, Clay County, St. Johns County, Bradford County, and all of Northeast Florida.
📞 Call or text Mike Schwiebert for a personalized consultation.